Re-check plasma Theophylline level 3 days after dose adjustment (4-6 hours after morning dose). Theophylline products are Elixophyllin®, Theobid®, Theo-24®, T … Aminophylline is soluble in water and insoluble in alco­hol. It has a role as a vasodilator agent, a bronchodilator agent, a muscle relaxant, an EC 3.1.4. Aminophylline hydrate 1.09mg = theophylline 0.86mg. It is structurally similar to caffeine and is found in green and black tea. Theophylline occurs as bitter-tasting, odorless, white, crystalline powder with a … Design Systematic review and meta-analysis with application of Grading of Recommendations, Assessment, Development and Evaluation system. What are theophylline agents ("maintenance" or "long-term control") bronchodilators for chronic obstructive pulmonary disease (COPD)? Aminophylline is a methylated xanthine derivative. Even with aminophylline injection still commonly used, the ethylenediamine only serves to increase pH sufficiently to dissolve theophylline at the packaged concentration. As nouns the difference between theophylline and aminophylline is that theophylline is theophylline while aminophylline is a bronchodilator comprising theophylline and ethylenediamine in a 2:1 ratio. Product Choice. 5 Almost identical concentration-time curves were found for theophylline and aminophylline in Theophylline, also known as 1,3-dimethylxanthine, is a phosphodiesterase inhibiting drug used in therapy for respiratory diseases such as chronic obstructive pulmonary disease (COPD) and asthma under a variety of brand names. Since aminophylline is a salt that contains approximately 80% theophylline by weight, lower doses of theophylline can achieve the same reversal effects. (2) In practice, a conversion of aminophylline hydrate 1mg = theophylline 0.8mg is used. Data sources PubMed/MEDLINE, Embase, Google Scholar and Cochrane renal group were searched from 1970 to … Theophylline agents include theophylline products and aminophylline products. When given to dogs, it is often dosed at around 4.5 – 5 mg/lb three times daily for symptoms resulting from a mildly collapsed trachea (less than 50% collapsed). Intravenous Aminophylline usually continues for 24+ hours If oral Theophylline commenced: See table below to calculate suggested dose dependent upon Infusion Rate. Objective To compare the efficacy and safety of theophylline or aminophylline for prevention of acute kidney injury (AKI) in neonates and children. Theophylline is available in several brands with different dosage schedules. Aminophylline is a combination of theophylline and ethylenediamine. Several sustained-release preparations of theophylline and aminophylline that are absorbed at a constant rate provide steady plasma concentrations over a 12- to 24-hour period . Aminophylline occurs as bitter-tasting, white or slightly yellow granules or powder with a slight ammoniacal odor and a pK a of 5. The serum concentration of theophylline was measured by high pressure liquid chromatography. (3) Therefore, 250mg aminophylline hydrate = theophylline 200mg. It is a combination of theophylline (the active component) and ethylenediamine, which is a compound that increases the solubility of theophylline but has no known intrinsic pharmacological effects. Theophylline is a dimethylxanthine having the two methyl groups located at positions 1 and 3. The mechanisms of action of aminophylline are not completely understood. All dosage and labeling of theophylline formulations should therefore be in terms of the anhydrous theophylline content. The recommended doses for bronchodilatation are 200 to 400 mg twice daily, but one-half of these doses may be effective as an antiinflammatory treatment. 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